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Chromosome construction control laboratory (Yuko Takayama laboratory)
Chromosome construction control laboratory (Yuko Takayama laboratory)

高山優子

In our laboratory, we are conducting research on "what kind of mechanism is the chromosome maintained stably?". We are focusing on histones and histone variants CENP-A, which are important constituents of chromosomes. We have discovered the histone transcription factor of fission yeast and are currently elucidating the function of the molecule. In addition, we have begun research on transcriptional regulation of histone variants, which has not been reported so far. The laboratory basically conducts experiments every day from 9:00 to 5:00 on weekdays. Through my graduation research, I hope that I will be able to solve problems and think logically. I hope you find the research fun, even if only a little.

Basic Information

Faculty name/Affiliation Yuko Takayama / Department of Biosciences Faculty of Faculty of Science and Engineering and Engineering
Specialized Fields Molecular cell biology
Research theme Molecular analysis of histone transcriptional regulation, elucidation of chromosome partitioning mechanism
Research keywords Chromosomes, yeasts, centromeres, histones
Faculty introduction URL https://www3.med.teikyo-u.ac.jp/profile/ja.ec2493a9444a6382.html

Our Research

Elucidation of chromosome construction principle

Using fission yeast as a research material, we are studying the chromosome construction process using a histone transcription approach.

Papers and Conferences Presentation

Paper presentation

     
Title Laboratory Contents
Strains and approaches for genetic crosses in the oleaginous yeast Lipomyces starkeyi Chromosome construction control laboratory detail

     
Title Laboratory Contents
Identification of Genes Encoding CENP-A and Heterochromatin Protein 1 of Lipomyces starkeyi and Functional Analysis Using Schizosaccharomyces pombe Chromosome construction control laboratory detail

     
Title Laboratory Contents
Characterisation of functional domains in fission yeast Ams2 that are required for core histone gene transcription Chromosome construction control laboratory detail

Conference presentation

Title Society name Laboratory Contents
Genetic analysis by mating of fat-producing yeast Lipomyces starkeyi 54th Yeast Genetics Forum Research Report Meeting Chromosome construction control laboratory detail
Understanding the evolution of heterochromatin from the fat-producing yeast Lipomyces starkeyi The 44th Japanese Society of Molecular Biology Chromosome construction control laboratory detail
Establishment of genetic analysis method for fat-producing yeast The 93rd Genetics Society of Japan Chromosome construction control laboratory detail

Title Society name Laboratory Contents
Functional analysis of centromere-related factors with RNA recognition motif Yeast Genetics Forum Chromosome construction control laboratory detail
Attempt to develop molecular biological method for fat-producing yeast Japan Society for Molecular Biology Chromosome construction control laboratory detail

Title Society name Laboratory Contents
Molecular elucidation of fission yeast histone transcription factor Ams2. Yeast Genetics Forum Chromosome construction control laboratory detail
Homocomplex formation of Ams2 required for efficient core histone gene expression in fission yeast International Fission Yeast Conference Chromosome construction control laboratory detail
Molecular Elucidation of Histone Transcriptional Regulation in Fission Yeast Japan Society for Molecular Biology Chromosome construction control laboratory detail
Functional analysis of centromere-related proteins with RNA-binding domains Japan Society for Molecular Biology Chromosome construction control laboratory detail
Chromosome Workshop / Nuclear Dynamics Study Group Chromosome construction control laboratory detail
Analysis of molecular mechanisms that activate histone transcription Chromosome Workshop / Nuclear Dynamics Study Group Chromosome construction control laboratory detail

Title Society name Laboratory Contents
Determination of the promoter active region of the cnp1 gene Division of Microbiology The Molecular Biology Society of Japan Chromosome construction control laboratory detail

Introducing the FacultyThis section introduces details about the research and the passionate thoughts around the research.

高山優子准教授の紹介

Discover the fascinating and untold stories behind the cutting-edge research being conducted by our esteemed professors. Get an in-depth look at the motivations and passions driving their work, and learn how their findings are making a real impact on society. Don't miss the opportunity to gain a deeper understanding of the amazing work being done right here at our laboratory!

Introduction of Yuko Takayama